Odnokoz Olena, Nakatsuka Kyle, Klichko Vladimir I

Previously, we have shown that flies under-expressing the two mitochondrial peroxiredoxins (Prxs), dPrx3 and dPrx5, display increases in tissue-specific apoptosis and dramatically shortened life span, associated with a redox crisis, manifested as changes in GSH:GSSG and accumulation of protein mixed disulfides. To identify specific pathways...

Ben-Arfa Basam A E, Salvado Isabel M Miranda, Ferreira José M F

We have developed an innovative, rapid sol-gel method of producing hydroxyapatite nanopowders that avoids the conventional lengthy ageing and drying processes (over a week), being 200 times quicker in comparison to conventional aqueous sol-gel preparation, and 50 times quicker than ethanol based sol-gel synthesis. Two different sets of...

img 2017, Current opinion in behavioral sciences (NLD)

Bachi Keren, Sierra Salvador, Volkow Nora D

Drug-addiction may trigger early onset of age-related disease, due to drug-induced multi-system toxicity and perilous lifestyle, which remains mostly undetected and untreated. We present the literature on pathophysiological processes that may hasten aging and its relevance to addiction, including: oxidative stress and cellular aging, inflammation...

Bruno Rosa Maria, Duranti Emiliano, Ippolito Chiara

We evaluated whether vascular remodeling is present in physiological aging and whether hypertension accelerates the aging process for vascular function and structure. Small arteries from 42 essential hypertensive patients (HT) and 41 normotensive individuals (NT) were dissected after subcutaneous biopsy. Endothelium-dependent vasodilation...

Salthouse Timothy A

Decompose cognitive change into influences unique to particular cognitive domains, and influences shared across different cognitive domains.

img 2017, Biochemical and biophysical research communications (USA)

Cuanalo-Contreras Karina, Park Kyung-Won, Mukherjee Abhisek

Recent evidence suggests that during aging there is widespread accumulation of aggregated insoluble proteins, even in the absence of pathological conditions. Pharmacological manipulation of protein aggregation might be helpful to unveil the involvement of protein aggregates during aging, as well as to develop novel strategies to delay aging. Here...

Castro-Gutiérrez Víctor, Masís-Mora Mario, Diez María Cristina

The aim of this work was to determine the efficiency of a straw/compost/soil biomixture for pesticide depuration during its aging and continuous use, for a period of over a year, based on its capacity to remove carbofuran (CFN), while simultaneously monitoring the variations in microbial community structure. Successive CFN spikings were applied in...

Diggins Emma, Kelley Rachael, Cottrell David

Characteristics of self-harm differ across ages, but there is little work identifying age-related differences in younger people. Young people entering adolescence face emotionally and developmentally different challenges to those entering adulthood. This study investigates how Emergency Department (ED) presentations and management of self-harm...

Akinyemiju Tomi, Ogunsina Kemi, Okwali Michelle

Few studies have examined cancer-related risk factors in relation to SES across the lifecourse in low to middle income countries. This analysis focuses on adult women in India, China, Mexico, Russia and South Africa, and examines the association between individual, parental and lifecourse SES with smoking, alcohol, BMI, nutrition and physical...

img 2017, Frontiers in bioscience (Landmark edition) (USA)

Kyriazis Marios

While the current paradigm of research into ageing relies heavily upon reductionist premises, and it has clearly not produced any of the dramatic benefits anticipated in our fight against ageing, the majority of scientists are hesitant, unable or unwilling to consider different or alternative models. In this paper I will discuss some of the...

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